Search Result

Search Results for " serine/threonine kinase "

Targets

Compounds

Natural Products

Recombinant Proteins

Libraries

Cat No.	Product Name	Synonyms	Targets
T5456	WNK-IN-11	Allosteric WNK Kinase Inhibitor	Serine/threonin kinase
	WNK-IN-11 (Allosteric WNK Kinase Inhibitor) is an allosteric With-No-Lysine (WNK) kinase inhibitor,WNK1(IC50 : 4 nM)		Serine/threonin kinase
T8866	GW779439X		Apoptosis , Antibacterial , CDK , Aurora Kinase
	GW779439X is an inhibitor of CDK.		Apoptosis , Antibacterial , CDK , Aurora Kinase
T10547	BioE-1115		Serine/threonin kinase , Casein Kinase
	BioE-1115 is a selective and potent inhibitor of serine-threonine protein kinase (PASK, IC50 = 4 nM). BioE-1115 is a potent inhibitor of CK2α (IC50 = 10 μM).		Serine/threonin kinase , Casein Kinase
T3041	ALK inhibitor 2		FAK , ALK
	ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.		FAK , ALK
T10285	ALK inhibitor 1		FAK , IGF-1R , ALK
	ALK inhibitor 1 is a selective ALK kinase inhibitor.		FAK , IGF-1R , ALK
T62684	ATM Inhibitor-5
	ATM Inhibitor-5 [formula (1)] is a potent inhibitor of the serine/threonine protein kinase ATM.
T1911	Afuresertib	GSK2110183C,GSK2110183	ROCK , Akt , PKC
	Afuresertib (GSK2110183) is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity.		ROCK , Akt , PKC
T10727	Cdc7-IN-5		CDK
	Cdc7-IN-5 is a potent inhibitor of Cdc7 kinase. Cdc7, a serine-threonine protein kinase enzyme, is essential for the initiation of DNA replication in the cell cycle.		CDK
T11942	MAP4K4-IN-3	Compound 17	MAPK
	MAP4K4-IN-3 (Compound 17) may be a viable target for antidiabetic agents, a serine/threonine protein kinase.		MAPK
T9589	SI-113		SGK
	SI-113 is a potent and selective inhibitor of SGK1, a serine/threonine protein kinase, that modulates several oncogenic signaling cascades.		SGK
T7151	GSK2982772		RIP kinase
	GSK2982772 is an inhibitor of receptor interacting serine/threonine kinase 1 (RIPK1)with IC50 values of 16 nM and 20 nM for human and monkey RIP1, respectively.		RIP kinase
T60688	MKI-1	MASTL Kinase Inhibitor-1	Others
	MKI-1 (MASTL Kinase Inhibitor-1) is an inhibitor of MASTL (microtubule-associated serine/threonine kinase-like, IC50= 9.9 μM). MKI-1 exerts radiosensitizer and antitumor activities through PP2A activation in breast cance...		Others
T77333L	(Iso)-BMT-124110 Formate	(R)-N-(8-((2-amino-2,4-dimethylpentyl)oxy)-5H-chromeno[3,4-c]pyridin-2-yl)acetamide Formate（1679370-98-9 Free base）	AAK1 (AP2 associated kinase 1)
	(Iso)-BMT-124110 Formate has an inhibitory effect on the protein serine/threonine kinase AAK, and is used in the treatment of Parkinson's disease, schizophrenia, neuropathic pain, and Alzheimer's disease.		AAK1 (AP2 associated kinase 1)
T6496	Vactosertib	TEW-7197,EW-7197	ALK , TGF-beta/Smad
	Vactosertib (EW-7197) is an orally bioavailable inhibitor of the serine/threonine kinase, transforming growth factor (TGF)-beta receptor type 1 (TGFBR1), also known as activin receptor-like kinase 5 (ALK5), with potentia...		ALK , TGF-beta/Smad
T10406	Tuvusertib	M1774,ATR inhibitor 1	Apoptosis , ATM/ATR , Others , Chk
	Tuvusertib (M1774) is an orally available ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor (Ki< 1 µΜ) with selective and potentially antitumor activity.Tuvusertib selectively inhibits ATR activity and blocks...		Apoptosis , ATM/ATR , Others , Chk
T34973	Tyrphostin 8	4-Hydroxybenzylidenemalononitrile	EGFR , GTPase
	Tyrphostin 8(4-Hydroxybenzylidenemalononitrile) is a potent GTPase inhibitor that inhibits EGFR kinase with an IC50 of 560 μM.Tyrphostin 8 inhibits protein serine/threonine calmodulin phosphatases (IC50=21 μM), enhances ...		EGFR , GTPase
T6904	Necrosulfonamide	(E)-Necrosulfonamide	MLK
	(E)-Necrosulfonamide ((E)-Necrosulfonamide) is an inhibitor of necroptosis. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during nec...		MLK
TP1875L	CDK2 acetate(255064-79-0 free base)		Others
	CDK2 acetate is a member of the eukaryotic S/T protein kinase family and its function is to catalyze the phosphoryl transfer of ATP γ-phosphate to serine or threonine hydroxyl (denoted as S0/T0) in a protein substrate.		Others
T3980	Su1498	Tyrphostin SU 1498,AG 1498	VEGFR
	Su1498 (Tyrphostin SU 1498) is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2 (VEGFR2, aka FLK1; IC50 = 700 nM), having negligible activity at several other serine/threonine and tyrosine kinases.1,...		VEGFR
T37207L	Cdk5 Substrate acetate		CDK
	Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine kinase that is predominantly active in neuronal tissues. With p25 or p35, Cdk5 phosphorylates a range of proteins, including histone H1 and tau. Cdk5 Substrate aceta...		CDK
T4230	PF-3758309 hydrochloride	PF-03758309 hydrochloride	Apoptosis , PAK
	PF-3758309 hydrochloride (PF-03758309 hydrochloride) , is a PAK4 inhibitor, is also a n orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. PF-3758309 hyd...		Apoptosis , PAK
T6334	Ridaforolimus	AP23573,Deforolimus,MK-8669	mTOR , Autophagy
	Ridaforolimus (AP23573) is a small molecule and non-prodrug analogue of the lipophilic macrolide antibiotic rapamycin with potential antitumor activity. Ridaforolimus binds to and inhibits the mammalian target of rapamyc...		mTOR , Autophagy
T3579	PLX8394		Raf
	PLX8394 is an orally active inhibitor of serine/threonine-protein kinase B-Raf (BRAF) protein. PLX8394 can selectively bind to and inhibit the activity of both wild-type and mutated forms of BRAF, then inhibit the prolif...		Raf
T11375	GCN2iB		Others , Autophagy
	GCN2iB is an ATP-competitive inhibitor of a serine/threonine-protein kinase general control nonderepressible 2 (GCN2), with an IC50 of 2.4 nM.		Others , Autophagy
T35856	BMS-986176		AAK1 (AP2 associated kinase 1)
	AAK1-IN-1 (example 123) is an AAK1 (adaptor associated kinase 1) inhibitor with an IC50 of 2.2 nM. AAK1-IN-1 can be used for neurodegenerative diseases research[1]. Adaptor associated kinase 1 (AAK1) is a member of the A...		AAK1 (AP2 associated kinase 1)
T39466	Tilpisertib	GS-4875
	Tilpisertib is a serine/threonine kinase inhibitor (WO2017007689).
T30298	BAY1143269	BAY 1143269,BAY-1143269
	BAY1143269 is an orally effective mitogen-activated protein kinase-interacting serine/threonine-protein kinase 1 (MKNK1) inhibitor with potential anti-tumor activity.
T69711	Flizasertib
	Flizasertib is a serine/threonine kinase inhibitor .
TP1875	CDK2
	CDK2, a eukaryotic S/T protein kinase family member, catalyzes the phosphoryl transfer from ATP γ-phosphate to the hydroxyl of serine or threonine (denoted as S0/T0) in a protein substrate.
TP1056	Phosphorylase Kinase β-Subunit Fragment (420-436)	Phosphorylase Kinase β-Subunit(420-436),Phosphorylase Kinase β-Subunit Fragment 420-436
	Phosphorylase Kinase β-Subunit Fragment (420-436) is a peptide fragment (430-436) derived from the β-Subunit of phosphorylase kinase. Phosphorylase kinase, a serine/threonine-specific protein kinase, plays a crucial role...
T13846	PROTAC RIPK degrader-2		Others
	PROTAC RIPK degrader-2 is a nonpeptidic PROTAC ,and potently targets serine-threonine kinase RIPK2 and has highly selective for RIPK2 degradation.		Others
T10436L	AZD4573 HCl (2057509-72-3 free base)	AZD4573 hydrochloride,AZD4573,AZD4573 HCl,AZD-4573,AZD 4573
	AZD-4573 is a selective and short-acting inhibitor of the serine/threonine cyclin-dependent kinase 9, the catalytic subunit of the RNA polymerase II elongation factor positive transcription elongation factor b. It also h...
TP2269	MAP kinase fragment [Multiple species]		Others
	This Mitogen-activated protein kinase (MAP kinase) fragment has a peptide sequence of Lys-Tyr-Ile-His-Ser-Ala-Asn-Val-Leu. The MAP kinases are serine/threonine-specific protein kinases belonging to the CMGC (CDK/MAPK/GSK...		Others
T26981	Ceralasertib formate	Ceralasertib,AZD-6738,AZD 6738,AZD6738
	Ceralasertib is an orally available inhibitor of ataxia telangiectasia and rad3 related (ATR) kinase. Ceralasertib selectively inhibits ATR activity by blocking the downstream phosphorylation of the serine/threonine prot...
T65212	β-Glycerophosphate Disodium Salt Hydrate (2:1:4)
	β-Glycerophosphate Disodium Salt Hydrate is a classical serine-threonine phosphatase inhibitor used in kinase reaction buffers often used in combination with other phosphatase/protease inhibitors for broad spectrum inhib...
T35489	1-O-Octadecyl-2-O-methyl-sn-glycerol
	1-O-Octadecyl-2-O-methyl-sn-glycerol is a metabolite of a phosphotidylinositol ether lipid analog (PIA). PIAs are known to target the pleckstrin homology domain of the serine/threonine kinase Akt and to induce apoptosis ...
T37207	Cdk5 Substrate	Cdk5 Substrate
	Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine kinase that is predominantly active in neuronal tissues. With p25 or p35, Cdk5 phosphorylates a range of proteins, including histone H1 and tau. Cdk5 substrate is a ...
T69091	CBP501
	CBP501 is a peptide with G2 checkpoint-abrogating activity. G2 checkpoint inhibitor CBP501 inhibits multiple serine/threonine kinases, including MAPKAP-K2, C-Tak1, and CHK1, that phosphorylate serine 216 of the dual-spec...
T61224	Cdc7-IN-8
	Cdc7-IN-8, a potent inhibitor, targets Cdc7, a serine/threonine kinase responsible for activating MCM promotion through phosphorylation of the microchromosome maintenance protein (MCM protein). MCM protein, an essential ...
T61663	SBI-581
	SBI-581 is an orally active, potent selective inhibitor of serine-threonine kinase TAO3, with an IC 50 of 42 nM. It effectively promotes the accumulation of TKS5α at RAB11-positive vesicles and inhibits the formation of ...
T36643	PKI-166 hydrochloride
	Potent EGFR-kinase inhibitor (IC50 = 0.7 nM). Displays >3000-fold selectivity against a panel of serine/threonine kinases. Reduces metastasis and angiogenesis in a mouse model of pancreatic cancer. Antihypertensive and o...
T81850	MASTL-IN-2
	MASTL-IN-2 is a potent inhibitor of microtubule-associated serine/threonine kinase-like (MASTL). It demonstrates notable efficacy in suppressing the proliferation of human epithelial MIA PaCa cancer cells, exhibiting an ...
T76388	Protein kinase C α peptide TFA
	Protein Kinase C (alpha) Peptide (TFA) is a PKC-α-associated peptide functioning as a lipid-dependent serine/threonine protein kinase. It plays a pivotal role in regulating several cellular functions such as survival, pr...
T63541	HPK1-IN-27
	HPK1-IN-27 is a potent inhibitor of HPK1. Among them, MAP4K1, also known as hematopoietic progenitor kinase 1 (HPK1), is a member of the germinal center kinase family and is a serine/threonine kinase. HPK1-IN-27 has show...
T36783	BPIQ-II (hydrochloride)
	BPIQ-II is a linear imidazoloquinazoline that potently inhibits the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 8 pM). It is selective for EGFR over an assortment of other tyrosine and ...
T81851	MASTL-IN-1
	MASTL-IN-1 is a potent inhibitor of microtubule-associated serine/threonine kinase-like (MASTL), which plays a role in cell proliferation, migration, and invasion, thereby holding promise in cancer research [1].
T83740	Ziptide TFA
	Ziptide, a peptide substrate, is recognized by several serine/threonine protein kinases, such as MAPK activated protein kinase 2 (MAPKAPK2), MAPKAPK3, MAPKAPK5, checkpoint kinase 1 (Chk1), AMP-activated protein kinase (A...
T71556	MK-1496
	MK1496 is a n orally bioavailable Polo-like kinase 1 (Plk1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor MK1496 selectively inhibits Plk1, inducing selective G2/M arrest followed by apop...
T71188	LY2780301
	LY2780301 is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor LY2780301 binds to and inhibits the activity of Akt, which...
T76008	Protein Kinase C (19-31) (TFA)
	Protein Kinase C (19-31) TFA is a peptide inhibitor derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31), featuring a serine substitution for alanine at position 25. It serves as a substrate pepti...

Compounds

WNK-IN-11

T5456

Synonym: Allosteric WNK Kinase Inhibitor

Target: Serine/threonin kinase

GW779439X

T8866

Synonym:

Target: Apoptosis, Antibacterial, CDK, Aurora Kinase

BioE-1115

T10547

Synonym:

Target: Serine/threonin kinase, Casein Kinase

Target: FAK, IGF-1R, ALK

Synonym: GSK2110183C,GSK2110183

Target: ROCK, Akt, PKC

Synonym: MASTL Kinase Inhibitor-1

Target: Others

(Iso)-BMT-124110 Formate

T77333L

Synonym: (R)-N-(8-((2-amino-2,4-dimethylpentyl)oxy)-5H-chromeno[3,4-c]pyridin-2-yl)acetamide Formate（1679370-98-9 Free base）

Target: AAK1 (AP2 associated kinase 1)

Vactosertib

T6496

Synonym: TEW-7197,EW-7197

Target: ALK, TGF-beta/Smad

Tuvusertib

T10406

Synonym: M1774,ATR inhibitor 1

Target: Apoptosis, ATM/ATR, Others, Chk

Tyrphostin 8

T34973

Synonym: 4-Hydroxybenzylidenemalononitrile

Target: EGFR, GTPase

Necrosulfonamide

T6904

Synonym: (E)-Necrosulfonamide

Target: MLK

CDK2 acetate(255064-79-0 free base)

Synonym: Tyrphostin SU 1498,AG 1498

Target: VEGFR

Cdk5 Substrate acetate

T37207L

Synonym:

Target: CDK

PF-3758309 hydrochloride

T4230

Synonym: PF-03758309 hydrochloride

Target: Apoptosis, PAK

Ridaforolimus

T6334

Synonym: AP23573,Deforolimus,MK-8669

Target: mTOR, Autophagy

Target: Others, Autophagy

BMS-986176

T35856

Synonym:

Target: AAK1 (AP2 associated kinase 1)

Synonym: BAY 1143269,BAY-1143269

Phosphorylase Kinase β-Subunit Fragment (420-436)

TP1056

Synonym: Phosphorylase Kinase β-Subunit(420-436),Phosphorylase Kinase β-Subunit Fragment 420-436

Target:

PROTAC RIPK degrader-2

T13846

Synonym:

Target: Others

AZD4573 HCl (2057509-72-3 free base)

T10436L

Synonym: AZD4573 hydrochloride,AZD4573,AZD4573 HCl,AZD-4573,AZD 4573

Target:

MAP kinase fragment [Multiple species]

Synonym: Ceralasertib,AZD-6738,AZD 6738,AZD6738

Target:

β-Glycerophosphate Disodium Salt Hydrate (2:1:4)

T65212

Synonym:

Target:

1-O-Octadecyl-2-O-methyl-sn-glycerol

Synonym: Cdk5 Substrate

PKI-166 hydrochloride

Protein kinase C α peptide TFA

BPIQ-II (hydrochloride)

Protein Kinase C (19-31) (TFA)

T76008

Synonym:

Target:

Cat No.	Product Name	Synonyms	Targets
T7444	6-(Dimethylamino)purine	N,N-Dimethyladenine	Serine/threonin kinase , CDK
	6-(Dimethylamino)purine (N,N-Dimethyladenine) is a serine threonine protein kinase and CDK inhibitor		Serine/threonin kinase , CDK
T4915	β-Glycerophosphate disodium salt hydrate		Phosphatase , Endogenous Metabolite
	β-Glycerophosphate is a classical serine-threonine phosphatase inhibitor used in kinase reaction buffers. BGP is often used in combination with other phosphatase/protease inhibitors for broad spectrum inhibition. It func...		Phosphatase , Endogenous Metabolite

Natural Products

6-(Dimethylamino)purine

T7444

Synonym: N,N-Dimethyladenine

Target: Serine/threonin kinase, CDK

β-Glycerophosphate disodium salt hydrate

T4915

Synonym:

Target: Phosphatase, Endogenous Metabolite

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-01059	BMPR2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	BMPR2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.6 kDa and the accession number is Q13873.
TMPY-04407	LOK Protein, Human, Recombinant (His)	Human	E. coli
	Serine / threonine-protein kinase 1, also known as Lymphocyte-oriented kinase, STK1 and LOK, belongs to the protein kinase superfamily, STE Ser / Thr protein kinase family and STE2 subfamily. Protein kinases constitute a...
TMPY-04466	STK40 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	STK40 is localized to both the cytoplasm and the nucleus. It is ubiquitously expressed. Mechanistically, Stk40 interacts with Rcn2, which also activates Erk1/2 to induce ExEn specification in mouse ESCs. Stk40 is able to...
TMPY-04374	MST4 Protein, Human, Recombinant (GST)	Human	Baculovirus Insect Cells
	MST4, also known as mammalian STE2-like protein kinase 4, is a novel member of the germinal center kinase subfamily of human Ste2-like kinases and is closely related to MST3. The 416 amino acid full-length MST4 contains ...
TMPY-04468	STK16 Protein, Human, Recombinant (His & NusA)	Human	E. coli
	Serine/threonine-protein kinase 16, also known as myristoylated and palmitoylated serine/threonine-protein kinase, Protein kinase PKL12, TGF-beta-stimulated factor 1, TSF-1, MPSK1 and STK16, is a membrane protein that is...
TMPH-03456	CAK1 Protein, S. cerevisiae, Recombinant (His & Myc)	Saccharomyces cerevisiae	Baculovirus Insect Cells
	CAK1 Protein, S. cerevisiae, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 46.1 kDa and the accession number is P43568.
TMPH-03457	CAK1 Protein, S. cerevisiae, Recombinant (E. coli, His & Myc)	Saccharomyces cerevisiae	E. coli
	CAK1 Protein, S. cerevisiae, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 49.6 kDa and the accession number is P43568.
TMPY-04398	MST1 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	Dysregulation of MST1/STK4, a key kinase component of the Hippo-YAP pathway, is linked to the etiology of many cancers with poor prognosis. STK4/Hippo pathway may have important therapeutic implications for cancer. The t...
TMPH-00340	ATG1 Protein, Candida glabrata, Recombinant (His)	Candida glabrata	E. coli
	ATG1 Protein, Candida glabrata, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 38.4 kDa and the accession number is Q6FL58.
TMPY-05095	RAF1 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	RAF1 gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds direct...
TMPY-04424	MST3 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	Aberrant STK24 expression was an independent prognostic indicator in lung adenocarcinoma patients. Its dysregulation was associated with its DNA copy number alteration and methylation. STK24/CCM3-regulated exocytosis pla...
TMPY-02198	ILKAP Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Integrin-linked kinase-associated serine/threonine phosphatase 2C, also known as ILKAP, is a cytoplasm protein that belongs to the PP2C family. ILKAP contains one PP2C-like domain. ILKAP is widely expressed. Highest leve...
TMPH-01171	CDK5 Protein, Human, Recombinant	Human	E. coli
	CDK5 Protein, Human, Recombinant is expressed in E. coli.
TMPH-01173	CDK7 Protein, Human, Recombinant	Human	E. coli
	CDK7 Protein, Human, Recombinant is expressed in E. coli.
TMPY-00683	BMPR2 Protein, Human, Recombinant (His & hFc)	Human	HEK293 Cells
	BMPR2 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 42 kDa and the accession number is Q13873.
TMPH-01172	CDK7 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	CDK7 Protein, Human, Recombinant (His) is expressed in Baculovirus.
TMPJ-00325	BMPR1A/ALK-3 Protein, Human, Recombinant (hFc & His)	Human	HEK293 Cells
	Bone Morphogenetic Protein Receptor Type-1A (BMPR1A) belongs to the TKL Ser/Thr protein kinase family and TGFB receptor subfamily, including the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. BMPR1A i...
TMPJ-00304	ALK-1 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	Activin Receptor-Like Kinase 1 (ALK-1) is a type I cell-surface receptor for the TGF-β superfamily of ligands, which mediates signaling of BMP9 (bone morphogenetic protein) and BMP10. ALK1 signaling is necessary for angi...
TMPJ-00254	TGF beta 3 Protein, Human/Mouse/Rat, Recombinant	Human,Mouse,Rat	HEK293 Cells
	Transforming growth factor beta 3(TGFB3) is a member of a TGF -β superfamily which is defined by theirstructural and functional similarities. TGFB3 is secreted as a complex with LAP. This latent form of TGFB3becomes acti...
TMPY-02953	TEM8/ANTXR1 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	ANTXR1 contains 1 VWFA domain and belongs to the ATR family. ATR (Ataxia telangiectasia and Rad3 related) and ATM (Ataxia telangiectasia mutated) are closely related kinases that are activated by DNA damage. They are ser...
TMPY-04552	AKT1 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	v-akt murine thymoma viral oncogene homolog 1 (AKT1), or protein kinase B-alpha (PKB-ALPHA) is a serine-threonine protein kinase, belonging to the Protein Kinase Superfamily. AKT1 is a major mediator of the responses to ...
TMPY-04565	SRPK3 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	Serine / threonine-protein kinase SRPK3, also known as Muscle-specific serine kinase 1, Serine/arginine-rich protein-specific kinase 3, SR-protein-specific kinase 3, Serine / threonine-protein kinase 23, MSSK-1, SRPK3 an...
TMPY-04559	CDC42BPB Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	CDC42BPB is a member of the serine / threonine protein kinase family that contains a Cdc42 / Rsc-binding p21 binding domain similar to that of PAK kinase. The kinase domain of this protein is related to the myotonic dyst...
TMPH-03458	STE11 Protein, S. cerevisiae, Recombinant	Saccharomyces cerevisiae	E. coli
	Serine/threonine protein kinase required for cell-type-specific transcription and signal transduction in yeast. It is thought that it phosphorylates the STE7 protein kinase which itself, phosphorylates the FUS3 and or KS...
TMPY-04420	TLK1 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	Tousled-like kinase 1 (or protein kinase ubiquitous, PKU-beta/TLK1) is a serine/threonine protein kinase that is implicated in chromatin remodeling, DNA replication and mitosis. TLK1 has a function important for proper c...
TMPY-04357	RSK4 Protein, Human, Recombinant (GST)	Human	Baculovirus Insect Cells
	Ribosomal protein S6 kinase alpha-6, also known as Ribosomal S6 kinase 4, 9 kDa ribosomal protein S6 kinase 6,RSK-4, RSK4 and RPS6KA6, is a protein that belongs to the protein kinase superfamily, AGC Ser/Thr protein kina...
TMPY-04402	CSNK1G1 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	Casein kinase I isoform gamma-1, also known as CSNK1G1, is a member of the protein kinase superfamily, CK1 Ser/Thr protein kinase family and casein kinase I subfamily. Thecasein kinase I family of protein kinases are ...
TMPY-04463	CDKL2 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	Cyclin-dependent kinase-like 2 (Cdkl2) is a member of cdc2-related serine / threonine protein kinase family and it is found expressed in various brain regions, including the cerebral cortex, entorinal cortex, hippocampus...
TMPK-00972	PK-1/PROK1 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	PK-1 (Ac10) is a baculovirus-encoded serine/threonine kinase,a pk-1 knockout AcMNPV failed to produce infectious progeny, while the pk-1 repair virus could rescue this defect.the kinase activity of PK-1 is essential in r...
TMPY-04403	NLK/Nemo Like Kinase Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	Nemo-like kinase contains 1 protein kinase domain and belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, and MAP kinase subfamily. It also contains a TQE activation loop motif in which autopho...
TMPK-00677	PKA/PRKACA Protein, Canine, Recombinant (His)	Canine	E. coli
	The cAMP-dependent protein kinase PKA is a well-characterized member of the serine-threonine protein AGC kinase family and is the effector kinase of cAMP signaling. As such, PKA is involved in the control of a wide varie...
TMPH-02648	PKDCC Protein, Mouse, Recombinant (His & Myc)	Mouse	Baculovirus Insect Cells
	Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylati...
TMPY-04567	SRPK1 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	Serine / threonine-protein kinase SRPK1, also known as SFRS protein kinase 1, Serine/arginine-rich protein-specific kinase 1, SR-protein-specific kinase 1 and SRPK1, is a cytoplasm and nucleus protein that belongs to the...
TMPY-04406	Protein Kinase D2/PRKD2 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	Serine/threonine-protein kinase D2, also known as PRKD2 and PKD2, is a cytoplasm and membrane protein that belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family and PKD subfamily. PRKD2 / PKD2 is ...
TMPJ-01109	EIF4EBP2 Protein, Human, Recombinant (His)	Human	E. coli
	Eukaryotic Translation Initiation Factor 4E-Binding Protein 2 (EIF4EBP2) is a member of the Eukaryotic Translation Initiation Factor 4E Binding Protein Family. EIF4EBP2 regulates eIF4E activity by preventing its assembly...
TMPJ-00886	ATF1 Protein, Human, Recombinant (His)	Human	E. coli
	Cyclic AMP-dependent transcription factor ATF-1(ATF1) which contains 1 bZIP (basic-leucine zipper) domain and 1 KID (kinase-inducible) domain, belongs to the bZIP family. It influences cellular physiologic processes by r...
TMPH-02180	TTBK2 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother cent...
TMPJ-01074	PKCE Protein, Human, Recombinant (His)	Human	E. coli
	Protein Kinase C Epsilon type is a member of the serine- and threonine-specific protein kinase family that can be activated by calcium and the second messenger diacylglycerol. Protein Kinase C Epsilon contains these doma...
TMPJ-00314	ACVR2B Protein, Human, Recombinant (hFc & His)	Human	HEK293 Cells
	Activin proteins that belong to the transforming growth factor-beta (TGF-β) superfamily, exert their biological actions by binding to heteromeric receptor complexes of type I and type II serine/threonine kinase receptors...
TMPY-04373	CAMKII alpha/CAMK2A Protein, Human, Recombinant (GST)	Human	Baculovirus Insect Cells
	Ca2+/calmodulin-dependent protein kinase2A (CAMK2A) belongs to the serine/threonine protein kinase family and, together with other 28 different isoforms, belongs to the Ca2+/ calmodulin-dependent protein kinase subfamily...
TMPH-01539	ILK Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered ...
TMPJ-00944	PPP1CC Protein, Human, Recombinant (His)	Human	E. coli
	Serine/Threonine-Protein Phosphatase PP1-Υ Catalytic Subunit (PPP1CC) is a member of the PPP phosphatase family. It is essential for cell division, participates in the regulation of glycogen metabolism, muscle contractil...
TMPY-04456	PKC nu Protein, Human, Recombinant (GST)	Human	Baculovirus Insect Cells
	Serine/threonine-protein kinase D3, also known as Protein kinase C nu type, Protein kinase EPK2, PRKD3, EPK2 and PRKCN, is a cytoplasm and membrane protein that belongs to the protein kinase superfamily, CAMK Ser/Thr pro...
TMPY-04547	PBK/TOPK Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	PDZ binding kinase (PBK), also known as TOPK (T-LAK cell-originated protein kinase), is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family, and has all the chara...
TMPY-04399	TAOK3 Protein, Human, Recombinant (aa 1-411, His & GST)	Human	Baculovirus Insect Cells
	Serine/threonine-protein kinase TAO3, also known as cutaneous T-cell lymphoma-associated antigen HD-CL-9, CTCL-associated antigen HD-CL-9, Dendritic cell-derived protein kinase, JNK / SAPK-inhibitory kinase, Jun kinase-i...
TMPY-04412	Germinal Center Kinase/MAP4K2 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	Mitogen-activated protein kinase kinase kinase kinase 2, also known as B lymphocyte serine/threonine-protein kinase, Germinal center kinase, MAPK/ERK kinase kinase kinase 2, MEK kinase kinase 2, Rab8-interacting protein,...
TMPY-04417	DAPK1 Protein, Human, Recombinant (aa 1-363, His & GST)	Human	Baculovirus Insect Cells
	Death-associated protein kinase 1, also known as DAP kinase 1, DAPK1 and DAPK, is a cytoplasm protein which belongs to theprotein kinase superfamily, CAMK Ser / Thr protein kinase family and DAP kinase subfamily. DAPK...
TMPY-04540	S6K1/RPS6KB1 Protein, Human, Recombinant (GST)	Human	Baculovirus Insect Cells
	PS6K, also known as RPS6KB1, is a serine/threonine-protein kinase. It belongs to the RSK (ribosomal s6 kinase) family. Members of this family function in signal transduction. PS6K is an isoform of p70 ribosomal S6 kinase...
TMPY-04389	MAP3K8 Protein, Human, Recombinant (GST)	Human	Baculovirus Insect Cells
	Mitogen-activated protein kinase kinase kinase 8, also known as Cancer Osaka thyroid oncogene, Proto-oncogene c-Cot, Serine/threonine-protein kinase cot, Tumor progression locus 2 and MAP3K8, is a cytoplasm protein that ...
TMPY-04392	RSK3 Protein, Human, Recombinant (GST)	Human	Baculovirus Insect Cells
	Ribosomal protein S6 kinase alpha-2, also known as 9 kDa ribosomal protein S6 kinase 2, MAP kinase-activated protein kinase 1c, MAPK-activated protein kinase 1c, Ribosomal S6 kinase 3, RSK-3, RPS6KA2 and MAPKAPK1C, is a ...
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BMPR2 Protein, Human, Recombinant (His)

TMPY-01059

Species: Human

Expression System: HEK293 Cells

LOK Protein, Human, Recombinant (His)

TMPY-04407

Species: Human

Expression System: E. coli

STK40 Protein, Human, Recombinant (His & GST)

TMPY-04466

Species: Human

Expression System: Baculovirus Insect Cells

MST4 Protein, Human, Recombinant (GST)

TMPY-04374

Species: Human

Expression System: Baculovirus Insect Cells

STK16 Protein, Human, Recombinant (His & NusA)

TMPY-04468

Species: Human

Expression System: E. coli

CAK1 Protein, S. cerevisiae, Recombinant (His & Myc)

TMPH-03456

Species: Saccharomyces cerevisiae

Expression System: Baculovirus Insect Cells

CAK1 Protein, S. cerevisiae, Recombinant (E. coli, His & Myc)

TMPH-03457

Species: Saccharomyces cerevisiae

Expression System: E. coli

MST1 Protein, Human, Recombinant (His)

TMPY-04398

Species: Human

Expression System: Baculovirus Insect Cells

ATG1 Protein, Candida glabrata, Recombinant (His)

TMPH-00340

Species: Candida glabrata

Expression System: E. coli

RAF1 Protein, Human, Recombinant (His & GST)

TMPY-05095

Species: Human

Expression System: Baculovirus Insect Cells

MST3 Protein, Human, Recombinant (His)

TMPY-04424

Species: Human

Expression System: Baculovirus Insect Cells

ILKAP Protein, Human, Recombinant (His)

TMPY-02198

Species: Human

Expression System: HEK293 Cells

CDK5 Protein, Human, Recombinant

TMPH-01171

Species: Human

Expression System: E. coli

CDK7 Protein, Human, Recombinant

TMPH-01173

Species: Human

Expression System: E. coli

BMPR2 Protein, Human, Recombinant (His & hFc)

TMPY-00683

Species: Human

Expression System: HEK293 Cells

CDK7 Protein, Human, Recombinant (His)

TMPH-01172

Species: Human

Expression System: Baculovirus Insect Cells

BMPR1A/ALK-3 Protein, Human, Recombinant (hFc & His)

TMPJ-00325

Species: Human

Expression System: HEK293 Cells

ALK-1 Protein, Mouse, Recombinant (hFc)

TMPJ-00304

Species: Mouse

Expression System: HEK293 Cells

TGF beta 3 Protein, Human/Mouse/Rat, Recombinant

TMPJ-00254

Species: Human,Mouse,Rat

Expression System: HEK293 Cells

TEM8/ANTXR1 Protein, Human, Recombinant (hFc)

TMPY-02953

Species: Human

Expression System: HEK293 Cells

AKT1 Protein, Human, Recombinant (His)

TMPY-04552

Species: Human

Expression System: Baculovirus Insect Cells

SRPK3 Protein, Human, Recombinant (His & GST)

TMPY-04565

Species: Human

Expression System: Baculovirus Insect Cells

CDC42BPB Protein, Human, Recombinant (His & GST)

TMPY-04559

Species: Human

Expression System: Baculovirus Insect Cells

STE11 Protein, S. cerevisiae, Recombinant

TMPH-03458

Species: Saccharomyces cerevisiae

Expression System: E. coli

TLK1 Protein, Human, Recombinant (His & GST)

TMPY-04420

Species: Human

Expression System: Baculovirus Insect Cells

RSK4 Protein, Human, Recombinant (GST)

TMPY-04357

Species: Human

Expression System: Baculovirus Insect Cells

CSNK1G1 Protein, Human, Recombinant (His & GST)

TMPY-04402

Species: Human

Expression System: Baculovirus Insect Cells

CDKL2 Protein, Human, Recombinant (His)

TMPY-04463

Species: Human

Expression System: Baculovirus Insect Cells

PK-1/PROK1 Protein, Mouse, Recombinant (hFc)

TMPK-00972

Species: Mouse

Expression System: HEK293 Cells

NLK/Nemo Like Kinase Protein, Human, Recombinant (His & GST)

TMPY-04403

Species: Human

Expression System: Baculovirus Insect Cells

PKA/PRKACA Protein, Canine, Recombinant (His)

TMPK-00677

Species: Canine

Expression System: E. coli

PKDCC Protein, Mouse, Recombinant (His & Myc)

TMPH-02648

Species: Mouse

Expression System: Baculovirus Insect Cells

SRPK1 Protein, Human, Recombinant (His & GST)

TMPY-04567

Species: Human

Expression System: Baculovirus Insect Cells

Protein Kinase D2/PRKD2 Protein, Human, Recombinant (His & GST)

TMPY-04406

Species: Human

Expression System: Baculovirus Insect Cells

EIF4EBP2 Protein, Human, Recombinant (His)

TMPJ-01109

Species: Human

Expression System: E. coli

ATF1 Protein, Human, Recombinant (His)

TMPJ-00886

Species: Human

Expression System: E. coli

TTBK2 Protein, Human, Recombinant (His & Myc)

TMPH-02180

Species: Human

Expression System: E. coli

PKCE Protein, Human, Recombinant (His)

TMPJ-01074

Species: Human

Expression System: E. coli

ACVR2B Protein, Human, Recombinant (hFc & His)

TMPJ-00314

Species: Human

Expression System: HEK293 Cells

CAMKII alpha/CAMK2A Protein, Human, Recombinant (GST)

TMPY-04373

Species: Human

Expression System: Baculovirus Insect Cells

ILK Protein, Human, Recombinant (His)

TMPH-01539

Species: Human

Expression System: Baculovirus Insect Cells

PPP1CC Protein, Human, Recombinant (His)

TMPJ-00944

Species: Human

Expression System: E. coli

PKC nu Protein, Human, Recombinant (GST)

TMPY-04456

Species: Human

Expression System: Baculovirus Insect Cells

PBK/TOPK Protein, Human, Recombinant (His)

TMPY-04547

Species: Human

Expression System: Baculovirus Insect Cells

TAOK3 Protein, Human, Recombinant (aa 1-411, His & GST)

TMPY-04399

Species: Human

Expression System: Baculovirus Insect Cells

Germinal Center Kinase/MAP4K2 Protein, Human, Recombinant (His & GST)

TMPY-04412

Species: Human

Expression System: Baculovirus Insect Cells

DAPK1 Protein, Human, Recombinant (aa 1-363, His & GST)

TMPY-04417

Species: Human

Expression System: Baculovirus Insect Cells

S6K1/RPS6KB1 Protein, Human, Recombinant (GST)

TMPY-04540

Species: Human

Expression System: Baculovirus Insect Cells

MAP3K8 Protein, Human, Recombinant (GST)

TMPY-04389

Species: Human

Expression System: Baculovirus Insect Cells

RSK3 Protein, Human, Recombinant (GST)

TMPY-04392

Species: Human

Expression System: Baculovirus Insect Cells

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Cat No.	Product Name
L1400	MAPK Inhibitor Library	365 compounds
	A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;
L1300	PI3K-AKT-mTOR Compound Library	420 compounds
	A unique collection of 420 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved with PI3K/Akt/mTOR signaling;

Libraries

MAPK Inhibitor Library

L1400

Compounds: 365

PI3K-AKT-mTOR Compound Library

L1300

Compounds: 420